The midway point in CONMEBOL arrived on THU 06 OCT 2016, and the top teams began to pull away from the pack.

• Ecuador 03-00 Chile: A goal and an assist from Antonio VALENCIA led la Tri to victory. Since winning the Copa América Centenario four months ago, Chile have one point from three matches.
• Paraguay 00-01 Colombia: A stoppage time goal from substitute Edwin CARDENA broke the deadlock in Asunción, earning three points for the Cafeteros despite missing James RODRÍGUEZ due to injury.
• Peru 02-02 Argentina: A frantic second half saw Gonzalo HIGUAÍN put the visiting side ahead for a second time. Moments later, Argentina defender Ramiro FUNES MORI brought down Paolo GUERRERO in the area, and Christian CUEVA equalised on the spot kick.